Lithium orotate is a form of lithium combined with orotic acid , known for its good tolerability and ability to effectively penetrate cells, including the brain. While its benefits are still being researched, correct dosage is key to reaping its effects safely.
Unlike medical treatments with lithium carbonate , where high doses are used to treat bipolar disorder , lithium orotate is used in much smaller amounts , which significantly reduces the likelihood of side effects.
Is lithium orotate toxic? Dosage in the treatment of bipolar disorder
In medical treatment with lithium salts, such as carbonate, the therapeutic serum concentration is between 0.8 and 1.2 mM (mmol/L) . However, levels above 1.5 mM can be toxic, affecting organs such as the kidneys, liver, or heart .
This shows that lithium has a very narrow therapeutic margin ; that is, the difference between an effective and a toxic dose is minimal . For this reason, psychiatric treatments with lithium require medical supervision and regular monitoring .
For reference, 1 mg of lithium ingested in drinking water produces a blood concentration of approximately 0.0014 mM , which is barely one-thousandth of the toxic level. In contrast, to reach concentrations of 1.0 mM (as in clinical use), doses of around 200 mg of pure lithium , equivalent to 1 g of lithium carbonate per day , would be necessary.
Low doses and maintenance microdoses
For general prevention of neuroinflammation and maintenance of cognitive well-being, studies point to a microdose of around 1 mg of pure lithium per day .
This is roughly equivalent to:
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23 mg of lithium orotate = 2 mL of the liquid solution at 500 ppm.
These amounts are considered safe and much lower than pharmacological doses , so side effects are extremely unlikely.
However, in the EU, lithium orotate is not authorized as a food supplement. Our lithium orotate is offered exclusively for laboratory and research use . This information is provided for informational purposes for users in the United States or Canada, where the consumption of lithium orotate is permitted.
Important precautions
Although low doses of lithium orotate are well tolerated and non-toxic at the recommended dose, professional supervision is preferable in the following cases:
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Pre-existing kidney or liver disease
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Pregnancy and breastfeeding
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Use of other medications , especially antidepressants or diuretics
In these cases, the professional may adjust the dose or limit the duration of treatment (for example, from 1 to 3 months) to ensure safety.
Lithium orotate allows you to take advantage of the potential benefits of lithium with much lower and safer doses .
While medical treatment for bipolar disorder requires around 200 mg of pure lithium per day , a dose of 1 to 5 mg daily —equivalent to 23–115 mg of lithium orotate—could be sufficient to support brain health and reduce neuroinflammation, without risk of toxicity .
